Use traditional whole transcriptome profiling, and single cell whole transcriptome profiling to understand human pre-implantation development, undifferentiated human embryonic stem cells and differentiated human embryonic stem cells.
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View SamplesMouse hair follicles contain distinct epidermal stem cell populations that reside in their own microenvironments. To understand their molecular identities and surrounding microenvironments, each stem cell compartment was isolated from several different eGFP reporter mouse lines by FACS and their transcriptome data was obtained by RNA sequencing.
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View SamplesAn RNA-seq analysis was performed using zebrafish granule cells, Purkinje cells, IO neurons, and glial cells. The transcriptomes were sequenced using Illumina HiSeq with paired-end libraries employing the Quartz-seq method for low amount total RNA.
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View SamplesFunctional discrimination between normal centroblast and centrocyte obtained from human inflamed tonsils after cell sorting.
CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells.
Specimen part
View SamplesNo description.
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Sex, Specimen part, Cell line, Treatment
View SamplesRNAseq of YAC128 mice treated with pridopidine
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Sex, Age, Specimen part, Cell line, Treatment
View SamplesFACS RNAseq of transgenic lines pWUS and pYAB
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Specimen part
View SamplesRaw sequence reads are provided for RNA-seq of parental and transgenerational worms in which the P0 were treated with OP50 (control) or PA14.
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Sex, Specimen part, Cell line
View SamplesIdentifying transcriptional changes in adults, whose biology and behavior differsubstantially from developing animals, is important when evaluating adult phenotypes.Moreover, cell- and tissue-specific information is critical for understanding the biologyof multicellular animals. We used adult cell-specific isolation to identify thetranscriptomes of C. elegans'' major adult tissues (muscle, intestine, epidermis, andneurons).
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Sex, Specimen part, Cell line
View SamplesWe evaluated the therapeutic activity of the modified U1 particles in a mouse model affected by severe spinal muscular atrophy. ExSpeU1 introduced by germline transgenesis efficiently rescued the phenotype increasing SMN2 exon 7 splicing, SMN protein production and radically extending the life span.
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Sex, Age, Specimen part, Disease, Cell line
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