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accession-icon GSE116912
characterization of mesenchymal stem cell derived from N1-12 and 201B7 via mesoderm and neuroepithelia
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

We established new methods for differentiating hiPSCs into MSCs via mesoderm-like and neuroepithelium-like cells. We named MSCs via mesoderm-like as PSP-MSC, and MSCs via neuroepithelium-like cells.

Publication Title

No associated publication

Alternate Accession IDs

E-GEOD-116912

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE45662
Expression data from arabidopsis wild type (Col-0) and JAV1 RNAi plant
  • organism-icon Arabidopsis thaliana
  • sample-icon 10 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

JAV1 functions as a negative regulator to control plant defense. Defense-related genes were highly induced in JAV1 RNAi plants compared to wild-type plants in response to wounding or jasmonate treatments.

Publication Title

JAV1 controls jasmonate-regulated plant defense.

Alternate Accession IDs

E-GEOD-45662

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE135000
Expression data from Sprague Dawley rat lenses cultured for 4 days - addition of various inhibitors
  • organism-icon Rattus norvegicus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Gene 2.0 ST Array (ragene20st)

Description

We created a rat sugar cataract model and examined the effects of various inhibitors on lens clouding. Lenses were removed from 6-week-old SD rats and cultured in M199 medium containing 30 mM galactose.

Publication Title

Histone acetyltransferase and Polo-like kinase 3 inhibitors prevent rat galactose-induced cataract.

Alternate Accession IDs

E-GEOD-135000

Sample Metadata Fields

Age, Specimen part

View Samples
accession-icon GSE109696
ERG and FLI1 in endothelial cells
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

Alternate Accession IDs

E-GEOD-109696

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE75690
Expression data from CD8alpha positive dendritic cells
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

We screened a number of interferon inducible genes that may be involved in impeding HBV replication and found an anti-HBV activity in ISG20. ISG20 is an IFN-inducible 3- to 5-exonuclease, that degrades DNA and RNA and reduces antigen production in hepatocyte-derived cells

Publication Title

Interferon-stimulated gene of 20 kDa protein (ISG20) degrades RNA of hepatitis B virus to impede the replication of HBV in vitro and in vivo.

Alternate Accession IDs

E-GEOD-75690

Sample Metadata Fields

Specimen part, Treatment

View Samples
accession-icon GSE59695
Role of histone lysine demethylase LSD2 in hepatic metabolism
  • organism-icon Homo sapiens
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.

Alternate Accession IDs

E-GEOD-59695

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE55285
Expression data from undifferentiated human ES cell line, khES3, grown using complete, methionine, leucine or lysine deprived media and ES cell derived endoderm
  • organism-icon Homo sapiens
  • sample-icon 7 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.

Alternate Accession IDs

E-GEOD-55285

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE43762
Expression profiling of glioma initiating cells (GICs) in the sphere and differentiation conditions
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Glioma initiating cells (GICs) are considered responsible for the therapeutic resistance and recurrence of malignant glioma. To clarify the molecular mechanism of GIC maintenance/differentiation, we established GIC clones from GBM patient tumors having the potential to differentiate into malignant gliomas in mouse intracranial xenograft, and established an in vitro glioma induction system by using serum stimulation.

Publication Title

Glioma initiating cells form a differentiation niche via the induction of extracellular matrices and integrin αV.

Alternate Accession IDs

E-GEOD-43762

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE109662
Expression data in HUVECs treated with siERG, siFLI1, or both
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Endothelial-to-mesenchymal transition (EndMT) in which endothelial cells lose their characteristics and acquire mesenchymal property has recently been recognized as a driver of disease progression in wide range of pathologies. However, the regulatory mechanism of EndMT has not been fully understood. Here, we found that combined knockdown of two ETS family transcription factors, ERG and FLI1, induced EndMT. Hence, we analyzed functions of ERG and FLI1 using gene expression microarray and ChIP-seq to elucidate the regulatory mechanism of EndMT.

Publication Title

Downregulation of ERG and FLI1 expression in endothelial cells triggers endothelial-to-mesenchymal transition.

Alternate Accession IDs

E-GEOD-109662

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE62572
Global gene expression profiling human and Chimpanzee induced pluripotent stem (iPS) cell
  • organism-icon Pan troglodytes, Homo sapiens
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Gene expression study of human and Chimpanzee iPS cell.

Publication Title

New type of Sendai virus vector provides transgene-free iPS cells derived from chimpanzee blood.

Alternate Accession IDs

E-GEOD-62572

Sample Metadata Fields

Specimen part

View Samples

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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