The project investigated the role of Leucine-rich a2-glycoprotein 1 (LRG1) in the vascularization, immunogenicity and growth of B16F0 subcutaneous tumours in Control and LRG1 global knock out mice.
No associated publication
None
Sex, Age, Specimen part, Disease, Cell line
View SamplesNon Small Cell Lung Cancer (NSCLC) causes the premature death of over 1 million people worldwide each year, but remains inadequately understood at the molecular level. To provide new insights for NSCLC treatment we performed a molecular characterisation of wild type and platinum drugs resistance in A549 cells. Transcriptome profiling revealed contrasting patterns of gene expression in sensitive and resistant cells and identified genes whose expression was highly correlated with the platinum drugs. Our results revealed a gene set of 15 transcripts whose expression was highly correlated with platinum-resistance in NSCLC A549 cell lines.
No associated publication
None
Specimen part, Disease, Disease stage, Cell line, Subject, Compound
View SamplesCells were reprogrammed from cardiac fibroblasts to cardiomyocytes, in various conditions. These are the iCM cells (induced cardiomyocytes). There are both human and mouse arrays here, as seen below.
In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes.
Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.
Specimen part, Treatment
View SamplesCardiomyocyte-like cells can be reprogrammed from somatic fibroblasts by combinations of genes, providing a new avenue for cardiac regenerative therapy. Here we show that functional cardiomyocytes can be rapidly and efficiently generated from human fibroblasts by specific combination small molecules. Microarray analysis has been used to compare the expression profile of cardiomyocyte-like cells derived from human foreskin and lung fibroblasts, and human ES cell-derived cardiomyocytes.
Conversion of human fibroblasts into functional cardiomyocytes by small molecules.
Specimen part
View SamplesNeonatal hearts (P2) from wildtype, miR-1-1 null and miR-1-2 +/-: miR-1-1 +/- double heterozygote animals were isolated and total RNA was extracted with TRIzol (Invitrogen), following the manufacturers suggested protocol.
microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.
Specimen part
View SamplesExcessive or sustained glucocorticoid (GC) exposure causes muscle wasting. Paradoxically, moderate or transient GC exposure elicits ergogenic effects, evidenced by their widespread use as doping agents by endurance athletes and poorly understood efficacy in Duchenne muscular dystrophy (DMD), a genetic muscle wasting disease. While mechanisms underlying GC-mediated muscle wasting are well defined, the molecular basis for the latter remains unknown. In this arm of our studies, we compare expression profiles in quadriceps tissue from KLF15 transgenic (MTg) and non-Tg mice.
Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program.
Specimen part
View SamplesTo identify targets of miR-550a-3-5p in human colon cancer, HCT116 cell line expressing miR-550a-3-5p was subjected to Illumina microarrays.
No associated publication
Specimen part, Cell line
View SamplesThis SuperSeries is composed of the SubSeries listed below.
The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition.
Age, Specimen part, Cell line, Treatment
View SamplesThis SuperSeries is composed of the SubSeries listed below.
The lncRNA GATA6-AS epigenetically regulates endothelial gene expression via interaction with LOXL2.
Specimen part, Treatment
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