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accession-icon E-MEXP-1415
Transcription profiling time series of leaves from winter wheat grown under S and N-deficient conditions
  • organism-icon Triticum aestivum
  • sample-icon 36 Downloadable Samples
  • Technology Badge Icon Affymetrix Wheat Genome Array (wheat)

Description

Transcripomic analysis of leaf gene expression in S and N-deficient winter wheat during grain development. Tissue was harvested at anthesis and 7, 14 and 21 days post anthesis from experimental field plots.

Publication Title

Co-ordinated expression of amino acid metabolism in response to N and S deficiency during wheat grain filling.

Alternate Accession IDs

None

Sample Metadata Fields

Specimen part, Disease, Disease stage, Subject, Time

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accession-icon SRP173569
Pseudomonas aeruginosa strain:CCTCC AB93066 Transcriptome or Gene expression
  • organism-icon Pseudomonas aeruginosa
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 4000

Description

Pseudomonas aeruginosa transcriptomic profile exposed to Cr(VI)

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Specimen part, Disease

View Samples
accession-icon SRP073278
Glycine max and Phytophthora sojae infected Glycine max Transcriptome
  • organism-icon Glycine max
  • sample-icon 5 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2000

Description

Glycine max and Phytophthora sojae infected Glycine max Transcriptome

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Specimen part

View Samples
accession-icon SRP078675
Glycine max cultivar:Huipizhi Heidou and Liaodou 15 Raw sequence reads
  • organism-icon Glycine max
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina Genome Analyzer II

Description

The project was aim of search the different mechanism of resoonse to soybean cyst nematode and mining the candidate resisitance genes from next generation sequencing

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Specimen part, Disease, Disease stage

View Samples
accession-icon SRP077553
Transcriptome profile and gene expression in the human placenta
  • organism-icon Homo sapiens
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

In this study, we performed a NGS analysis to identify transcriptome landscape of the human placenta during uncomplicated single and twin pregnancy, to establish a pattern of normal placental genes expression for further comprehensive analyses. Additionall aim of these studies was to identify the differentially expressed transcripts of genes in single and twin pregnancy that may participate in human pregnancy.

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Sex, Age, Specimen part, Disease

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accession-icon SRP145343
A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B)
  • organism-icon Danio rerio
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Mutations mapping to the RNA-binding interface of EXOSC3 have been linked to the rare neurological disorder known as Pontocerebellar Hypoplasia type1B (PCH1B). EXOSC3 is part of three putative RNA-binding structural cap proteinsthat guideRNA intothe RNA exosome, thecellular machinery that2degrades RNA. Here, using RNAcompete, we identifieda G-rich RNA motifthat requirestheK homology and ribosomal protein S1domains of EXOSC3. Interestingly, several PCH1B-causing mutations in EXOSC3do not engage this RNA motif. To test the hypothesis thatmodificationof the RNA-protein interface in EXOSC3 mutants may be phenocopied by small molecules, we performedan in silicoscreen of 50,000 small molecules and used enzyme-linked immunosorbant assays(ELISAs)to assess the ability ofthe molecules to inhibit RNA-bindingbyEXOSC3. We identified asmall molecule, EXOSC3-RNA disrupting (ERD) compound 3 (ERD03), which: (i) bound specifically to EXOSC3in saturation transfer difference nuclear magnetic resonance (STD NMR); (ii)disruptedthe EXOSC3-RNAinteraction in a concentration-dependent manner; (iii) induced an abnormal curved spine PCH1B-like phenotype in zebrafish embryos.This compound induced a comparable modification of RNA expression levels coupled with an atrophy of the cerebellum in the zebrafish. To our knowledge, this is the first example of a small molecule obtained by rational design thatmodelsthe abnormal developmental effectsof a neurodegenerative diseasein a whole organism.

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Sex, Age, Specimen part, Disease, Treatment

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accession-icon SRP142524
Viral coinfection of mouse respiratory system
  • organism-icon Mus musculus
  • sample-icon 45 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 4000

Description

Viral and bacterial coinfections are common in nature, but infrequently studied in laboratory models of infection. We observed disease severity differences in mice infected with two of three possible respiratory viruses, depending on the order of the infection. To discover the mechanisms causing these differences, we compared gene expression responses of lung tissue at three time points following viral coinfection. Differential gene expression and immune cell counts suggest a dampening of immune responses in mice infected with rhinovirus followed by influenza A virus or pneumonia virus of mice.

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Sex, Specimen part, Cell line, Treatment

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accession-icon SRP173029
Arabidopsis thaliana Transcriptome or Gene expression
  • organism-icon Arabidopsis thaliana
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Arabidopsis thaliana Transcriptome (Vv-circATS1-OE and WT under 4?)

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Specimen part

View Samples
accession-icon E-MTAB-3045
Transcription profiling by array of first leaf pair of amiPPD mutant and wild type Arabidopsis plants
  • organism-icon Arabidopsis thaliana
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

To obtain more insight into the molecular changes associated with PPD down-regulation, RNA was extracted from the first leaf pair of ami-ppd and wild-type plants at 13 DAS (the time point at which differences in leaf area start to be visible), and subjected to micro-array transcript profiling.

Publication Title

No associated publication

Alternate Accession IDs

None

Sample Metadata Fields

Specimen part, Time

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accession-icon E-MEXP-513
Transcription profiling of wild type and transgenic msi1-tap1 plants at two time points at the age of 8 days
  • organism-icon Arabidopsis thaliana
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Arabidopsis ATH1 Genome Array (ath1121501)

Description

Wild type and transgenic msi1-tap1 plants were grown and gene expression was compared at two time points at the age of 8 days.

Publication Title

Regulation of flowering time by Arabidopsis MSI1.

Alternate Accession IDs

None

Sample Metadata Fields

Age, Time

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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