Gene expression microarrays were performed to investigate the molecular effects of exposure to environmental polluted groundwater. Zebrafish was treated with polluted waters collected from dumps located upstream and downstream a sanitary landfills. Gene expression profiling of zebrafish liver was analyzed after acute exposure to sampled waters.
Cross-species toxicogenomic analyses and phenotypic anchoring in response to groundwater low-level pollution.
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Specimen part
View SamplesIn order to establish a statistical method to identify genetic and epigenetic factors on gene expression in Drosophila melanogaster, we measured gene expression level in female whole bodies obtained from two different sets of reciprocal crosses.
No associated publication
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Sex, Specimen part
View SamplesThe experiment was designed to enable comparison between columbia and MYB94 OX plants line Arabidopsis leaves
Overexpression of MYB94 Transcription Factor Causes Activation of Arabidopsis Cuticular Wax Biosynthesis
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Age, Specimen part
View SamplesWe compared the Galpha13 knockout and wild type mouse embryonic stem cells (cell line CJ7) to analyse the gene expression levels using Affymatrix mouse MGU_74Av2 array
Gene Expression Analysis of Galpha13-/- Knockout Mouse Embryos Reveals Perturbations in Galpha13 Signaling Related to Angiogenesis and Hypoxia
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Specimen part, Cell line, Time
View SamplesTranscriptional profiling of an Fd-GOGAT1/GLU1 mutant in Arabidopsis thaliana reveals a multiple stress response and extensive reprogramming of the transcriptome
Transcriptional profiling of an Fd-GOGAT1/GLU1 mutant in Arabidopsis thaliana reveals a multiple stress response and extensive reprogramming of the transcriptome.
Specimen part
View SamplesWe examined the effect of oral TUDCA treatment on hepatic steatosis and associated changes in hepatic gene expression in ob/ob mice.
Changes in hepatic gene expression upon oral administration of taurine-conjugated ursodeoxycholic acid in ob/ob mice.
Specimen part
View SamplesTo explore the biological changes of keratinocytes in condyloma acuminata (CA) warts, we performed mRNA and lncRNA expression profiling of keratinocytes from normal skins and warts of condyloma acuminata patients to compare the gene expression.
Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.
Specimen part
View SamplesReprogramming metabolism plays an important role in tumor cells for maintaining their abnormal biologic behaviors. Therefore, special factors could regulate metabolic processes and influence the overall status of tumor cells. This phenomenon was obviously found in melanoma. Fumarylacetoacetate hydrolase (fumarylacetoacetase, FAH) is an enzyme encoded by the FAH gene located on the chromosome 15q25.1 region and contains 14 exons. FAH enzyme catalyzes the hydrolysis of 4- fumarylacetoacetase into fumarate and acetoacetate. It is the last enzyme in the subpathway from L-phenylalanine and tyrosine degradation. Mutations in the FAH gene cause type I tyrosinemia, which is a hereditary error of metabolism that is characterized by increased tyrosine levels in the blood and urine of patients. In the present study, we will explore whether FAH is an essential enzyme to promote multiple metabolic processes and elucidate the functions of FAH in melanoma. Gene microarrays and bioinformatics analysis of the differentially expressed genes (DEGs) were performed using A375 cells, and we concentrated on the biologic functions of FAH. In general, our work revealed several functional mechanisms of FAH in melanoma, which indicated FAH might be a potentially therapeutic target and an independent prognostic indicator for this disease.
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Cell line
View SamplesThe role of lymphangiogenesis in tumor metastasis remains unclear. This study addressed this issue in lymphatic endothelial cells (LECs) derived from primary invasive breast cancer specimens.
Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C.
Specimen part, Disease
View SamplesWe analyzed changes in gene expression of Arabidopsis in response to 2 mM formaldehyde (HCHO) stimulation using cDNA microarray in the present study. The aim of our study was to identify HCHO-responsive genes and clarify the molecular mechanisms underlying the response of Arabidopsis to HCHO stress.
Physiological and transcriptional analysis of the effects of formaldehyde exposure on Arabidopsis thaliana
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Age, Specimen part, Compound, Time
View Samples