The effect of prototypical pregnane receptor X (PXR) agonist (pregnenolone 16-carbonitrile) PCN on hepatic gene expression was studied in mice primary hepatocytes.
Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver.
Sex, TreatmentView Samples
Calcific aortic valve disease is the most common form of valvular heart disease in the Western World. Milder degrees of aortic valve calcification is called aortic sclerosis and severe calcification with impaired leaflet motion is called aortic stenosis.
MicroRNA-125b and chemokine CCL4 expression are associated with calcific aortic valve disease.
Specimen part, Disease, Disease stageView Samples