Transcriptome profiling of MIR148A-TKO and wild-type hESC-derived cells on day 4 of cardiac differentiaton

To gain global insights into the transcriptomic response associated with MIR148A family knockout, we performed RNA sequencing (RNA-Seq) on hESC-differentiated cells on day 4 of cardiac differentiation for both WT and MIR148A-TKO groups. RNA-Seq analysis identified a total of 1837 differentially expressed genes in MIR148A-TKO and wild-type hESC-derived cells on day 4 of cardiac differentiaton. Furthermore, Gene Ontology enrichment analysis indicated knockout of all MIR148A family members inhibited lateral mesodermal and cardiac differentiation. Overall design: RNA-seq analysis of cells derived from both the MIR148A-TKO and wild-type hESCs on day 4 of cardiac differentiation.

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Fang X, Miao S, Yu Y, Ding F, Han X, Wu H, Zhao ZA, Wang Y, Hu S, Lei W