Effect of Rgnef knockout in an aggressive ovarian cancer cell line

SRP185891

Mus musculus

6 Downloadable Samples

Illumina HiSeq 4000

Submitter Supplied Information

Description

CRISPR/Cas9-mediated Rgnef knockout was performed in the aggressive ID8-IPs (alternaate name is KMF cells). Gene expression profiles of Rgnef-/- or Rgnef-/- cells re-expressing GFP-Rgnef were generated. Differential downregulation of antioxidant genes was observed in Rgnef-/- cells. Results provide insight into the role of Rgnef in promoting ovarian tumor progression. Overall design: mRNA profiles of ID8-KMF Rgnef-/- or Rgnef-/- cell re-expressing GFP-Rgnef were generated in triplicate using an Illumina HiSeq 4000.

PubMed ID

31308489

Publication Title

Rgnef promotes ovarian tumor progression and confers protection from oxidative stress.

Total Samples

Submitter’s Institution

No associated institution

Authors

Kleinschmidt EG, Miller NLG, Ozmadenci D, Tancioni I, Osterman CD, Barrie AM, Taylor KN, Ye A, Jiang S, Connolly DC, Stupack DG, Schlaepfer DD

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE126560

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