Single Cell RNA seq of Genetically Engineered Mouse Models of Pancreatic Adenocarcinoma

We report the scRNAseq profiles of three mouse models of pancreatic cancer: KIC, KPfC, KPC. Analyses demonstrate the existence of 2 molecular subtypes of cancer cells, 2 molecular subtypes of cancer associated fibroblasts, and 2 molecular subtypes of cancer associated macrophages. Overall design: Untreated mice were sacrificed at various time points prior to scRNA library generation: normal mouse at 60 days, early KIC mouse at 40 days, late KIC mouse at 60 days, late KPfC mouse at 60 days and KPC mouse at 6 months.

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Hosein AN, Huang H, Wang Z, Parmar K, Du W, Huang J, Maitra A, Olson E, Verma U, Brekken RA