Inhibition of Phosphoinositide-3-kinase signaling promotes the stem cell state of trophoblast

SRP180143

Mus musculus

12 Downloadable Samples

Illumina HiSeq 2500

Submitter Supplied Information

Description

We found that PI3K inhibition increased the expression of stem cell markers in trophoblast stem cells (TSCs). To better understand the PI3K inhibited cells, we compared untreated TSCs with cells treated with PI3K inhibitor ZSTK474 for 3h, 6h and 3 days. Overall design: Untreated TSCs, TSCs treated with 200nM ZSTK474 for 3h, 6h, and 3 days.

PubMed ID

31233251

Publication Title

Inhibition of Phosphoinositide-3-Kinase Signaling Promotes the Stem Cell State of Trophoblast.

Total Samples

Submitter’s Institution

No associated institution

Authors

Lee CQE, Bailey A, Lopez-Tello J, Sferruzzi-Perri AN, Okkenhaug K, Moffett A, Rossant J, Hemberger M

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE125301

No rows found