Combined MEKi (GDC-0973) and WNT (G007-LK) treatment in APC and KRAS mutant HCT-15 cell line

SRP173383

Homo sapiens

12 Downloadable Samples

Illumina HiSeq 2500

Submitter Supplied Information

Description

We report RNAseq data from HCT-15 cells were treated wih control(DMSO), GDC-0973, G007-LK and combined GDC-0973 and G007-LK treatmetn for 24 hours. Overall design: Three biological replicates of cultured HCT-15 cells treated with DMSO (0.02%), G007-LK (1µM), GDC-0973 (1µM) or G007-LK and GDC-0973 for 24 hours before Rna extraction

PubMed ID

30717152

Publication Title

MEK Inhibition Induces Canonical WNT Signaling through YAP in <i>KRAS</i> Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition.

Total Samples

Submitter’s Institution

No associated institution

Authors

Solberg NT, Melheim M, Strand MF, Olsen PA, Krauss S

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE123807

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