The scaffolding role of RNA in ribonucleoprotein complexes: TRA2A recruitment in FXTAS disease

To address the functional implications at highthroughput level of TRA2A recruitment in FXTAS nuclear inclusions we performed Clariom D splicing arrays with the COS-7 cell models. We compared the profiles of the cells upon CGG overexpression, TRA2A overexpression and knockdown, with the respective controls. Overall design: 18 samples were analyzed: controls (n=3); cond1 (n=3); cond2 (n=3); cond3 (n=3); cond4 (n=3); cond5 (n=3)

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Cid-Samper F, Gelabert-Baldrich M, Lang B, Lorenzo-Gotor N, Ponti RD, Severijnen LWFM, Bolognesi B, Gelpi E, Hukema RK, Botta-Orfila T, Tartaglia GG