Single cell transcriptomes of replicatively cellular senescenct cells and ionizing radiation induced senescent cells

In order to identify the transcriptome change and heterogeneity in replicative senescent cells and stress-induced senescent cells, =we measured 1600 single cell transcriptomes of young quiescent cells at a population doubling (PD) number of 38, middle age quiescent cells (PD = 48), replicative senescent (PD = 71) cells and 50Gy X-ray induced senescent cells of PD38 control cells by Drop-seq. Overall design: Drop-seq of RS and SIPS cells.

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Tang H, Geng A, Zhang T, Wang C, Jiang Y, Mao Z