The Lysosomal Transcription Factor TFEB regulates myelination downstream of the Rag-Ragulator complex.

Purpose: To identify genes that are differentially expressed in oligodendrocytes between control and rraga mutant zebrafish, we performed RNA seq using the Illumina platform Overall design: Oligodendrocytes were isolated from control and rraga mutant zebrafish at 5 days post fertilization using FACS sorting of Cldnk:GFP positive cells. RNA was extracted from these cells and sequenced using standard Illumina protocol.

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Meireles AM, Shen K, Zoupi L, Iyer H, Bouchard EL, Williams A, Talbot WS