Transcriptome wide change upon mitochondial stress in C.elegans

We discovered 5446 genes expression change (4218 genes from P0 to F2) in wild-type C.elegans transcriptome compared to DAMT-1 mutant upon mitochondrial stress by RNA-seq, which indicated those genes response to mitochondrial stress and may function in mitochondrial stress response. Overall design: Wild-type worms or damt-1 mutant were treated by mitochondrial inhibitor antimycin A from L1 to L4, then performed to NGS.

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Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A, Liu Y