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Accession IconSRP150084

Microtubule regulators act in the nervous system to modulate fat metabolism and longevity through DAF-16 in C. elegans

Organism Icon Caenorhabditis elegans
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Technology Badge IconIllumina HiSeq 3000

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Purpose: We found that mutations in microtubule regulating factors lead to altered lifespan. In order to understand the mechnaisms, we carried out RNA-seq analyses to identify genes with differential expression in microtubule regulator mutants. Overall design: Genetic mutants of efa-6, hdac-6, ptl-1 and ptrn-1 were compared to wildtype control. Synchronized Day 1 young adults were used for RNA extraction.
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