ADAR1-editing in HeLa, p150-KO and ADAR1-KO transcriptomes

SRP149377

Homo sapiens

12 Downloadable Samples

Illumina HiSeq 4000

Submitter Supplied Information

Description

RNAseq analysis of cell lines with ADAR1-p150 and ADAR1-p110 knock-outs and primary human tissue samples (from GSE57353 and GSE99392 data sets) to identify sites of ADAR1 editing Overall design: 12 samples: 3 cell lines (HeLa, HeLa-p150KO, HeLa-ADAR1KO) with four conditions each (no treatment, MeV-vac2(GFP)-infected, MeV-CKO(GFP)-infected, IFNA/D-treated). One biological replicate per sample. In addition, raw data files of 9 samples from series GSE57353 and GSE99392 were re-analyzed using the same data processing pipeline.

PubMed ID

30496178

Publication Title

Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150.

Total Samples

Submitter’s Institution

No associated institution

Authors

Pfaller CK, Donohue RC, Nersisyan S, Brodsky L, Cattaneo R

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE115127

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