Splicing and epigenetic factors jointly regulate epidermal differentiation

We report the effects of silencing SRSF1 or ZMAT2 in human epidermal stem cells on the transcriptome of epidermal stem cells. We found that silencing ZMAT2 or SRSF1 affects global splicing, however, ZMAT2 seems to regulate splicing of a smaller more specific subset of genes. Overall design: RNA-sequencing data following silencing SRSF1 or ZMAT2

9

Tanis SEJ, Jansen PWTC, Zhou H, van Heeringen SJ, Vermeulen M, Kretz M, Mulder KW