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Accession IconSRP139787

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence [RNA-Seq]

Organism Icon Homo sapiens
Sample Icon 48 Downloadable Samples
Technology Badge IconIllumina HiSeq 2500

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Description
We decribe the accessible chormatin landscape in RAS-induced (RIS) and NOTCH induced senescence (NIS) using ATAC-seq. By expressing active NOTCH (N1ICD) in the context of RIS, we find that N1ICD antagonises the formation of accessible regions in RIS. By performing co-cultures, we demonstrate that cells expressing a NOTCH1 ligand, JAGGED1, can antagonise the formation of RIS specific accessible regions. Overall design: mRNA profiles were IMR90 cells expressing ER:HRAS(G12V) and a control vector or MSCV miR30 shHMGA1 were generated. 6 biological replicates.
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48
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