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Accession IconSRP132654

The coding regions of germline mRNAs confer sensitivity to Argonaute regulation in the C. elegans germline

Organism Icon Caenorhabditis elegans
Sample Icon 7 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Some C. elegans transgenes resist piRNA silencing. Seth et al. map resistance to endogenous sequences within transgenes and show that artificially increasing piRNA targeting can incrementally reduce expression without silencing. Their findings identify coding regions as part of a rich piRNA regulatory landscape within perinuclear nuage.
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