Transcriptome Analysis of wild type and SMARCB1 knock down HL60 leukemia cell line by Next Generation Sequencing

We have used lentiviral mediated knock down of SMARCB1, a subunit of the mammalian SWI/SNF complex in HL60, an acute promyelocytic leukemia cell line followed by high throughput mRNA sequencing to identify differentially expressed genes. We have used this data to identify genes affected by SMARCB1 depletion, and thus understand contribution of SMARCB1 towards leukemogenesis.

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