a7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis.

We sequenced mRNA from 7 microglia extracted from sheep fetuses exposed to LPS, agonist and antagonist of a7 nicotinic acetylcholine receptor to determine signaling pathway through modeling of a7 during inflammation. Overall design: Examination of genetic expression in microglia after a7 nicotinic acetylcholine receptor modeling with agonistic and antagonistic drug.

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Cortes M, Cao M, Liu HL, Moore CS, Durosier LD, Burns P, Fecteau G, Desrochers A, Barreiro LB, Antel JP, Frasch MG