Signaling strength determines proapoptotic functions of STING

T cells exhibit an intensified STING response, which leads to the expression of a distinct set of genes and results in the induction of apoptosis Overall design: CD4+ T cells were stimulated either with DMSO or 10-carboxymethyl-9-acridanone (CMA) for 16 hours. RNA was isolated for analysis.

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Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A