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Accession IconSRP102746

Polyamide Efficacy in Enzalutamide-Resistant Prostate Cancer

Organism Icon Homo sapiens
Sample Icon 18 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
We report the biological activity of a Py-Im polyamide targeted to the sequence 5'-WGWWCW-3', which is found in a subset of ARE half-sites. This molecule reduces the growth of enzalutamide-resistant LREX' cells, both in vitro and in vivo. Gene expression changes associated with polyamide treatment in both settings are deposited here.
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