RNA-seq on biliary epithelial cells (BECs) of Klf5 LKO mice upon DDC injury

In other to assess functional involvement of Klf5 in DR regulation, we made liver-specific Klf5 knockout mice. Ductular reaction upon cholestatic liver injury is severely suppressed in these mice. We conducted RNA-seq analysis on the BECs from control mice and Klf5 LKO mice upon DDC injury to further elucidate the Klf5 functions. Overall design: Single-end RNA-seq of total RNAs extracted from BECs of Klf5 LKO mice upon DDC injury for 1wk

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Okada H, Yamada M, Kamimoto K, Kok CY, Kaneko K, Ema M, Miyajima A, Itoh T