Temperature adaptation effects on BAT metabolism in BAT specific Akt2 knockout mice

We are reporting here the effects of adaptation to different ambient temperatures in the whole genome gene expression of interscapular BAT of BAT specific Akt2 knockout mice Overall design: Wildtype littermates and brown fat specific Akt2 KO mice (using UCP1-CreER) in B6/J background were adapted to 2 different ambient temperatures (30ºC, 22ºC) for a period of 4 weeks.

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Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA