transcriptome analyses of zebrafish preovulatory follicle cells

To reveal downstream targets of progesterone receptor (Pgr) that are important for ovulation, RNA-seq analyses were performed on isolated follicle cell samples from individual wild-type and Pgr-KO fish (3 each). The results revealed over 3000 genes and multiple pathways were significantly different between two genotypes, providing the first resource of genome-wide data for investigating Pgr-regulated ovulatory genes in basal vertebrate.

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Liu DT, Brewer MS, Chen S, Hong W, Zhu Y