Identification of Transcripts Involved in Neural Tube Closure Using RNA-sequencing

The transcriptome of zebrafish embryos treated with a Nodal signaling inhibitor at sphere stage, which causes neural tube defects, is compared to those treated at 30% epiboly, which does not. Overall design: Transcriptomic analysis of differential gene expression of key developmental pathways under differing inhibitory treatments.

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Kindt LM, Coughlin AR, Perosino TR, Ersfeld HN, Hampton M, Liang JO