Molecular characterization of the ZSF1 rat model of Progressive DN by RNA-Seq

ZSF1 rats are a model of spontaneous nephropathy secondary to obesity, hypertension, and diabetes that have gained interest as a model system with potentially high translational value to progressive human disease. To thoroughly characterize this model, and to better understand how closely it recapitulates human disease, we performed a high resolution longitudinal analysis of disease progression in ZSF1 rats spanning from early renal disease to end stage renal disease.

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Dower K, Zhao S, Schlerman FJ, Savary L, Campanholle G, Johnson BG, Xi L, Nguyen V, Zhan Y, Lech MP, Wang J, Nie Q, Karsdal MA, Genovese F, Boucher G, Brown TP, Zhang B, Homer BL, Martinez RV