KAT6A determines CD8+ T cell diversity via regulation of co-receptors

To identify genes specifically expressed in WT or Kat6a knockout CD8+ T cells, the gene expression profiles of T cell subsets from naïve or LCMV WE infected mice were compared. Overall design: Three wildtype and three Kat6a knockout P14 transgenic mice were infected with LCMV WE for 8 days. Two wildtype and two knockout mice were uninfected. CD8+ T cells were harvested from the spleens of all mice. In the infected cohort, the T cells were further subsetted into KLRG1+ and KLRG1-.

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Newman DM, Sakaguchi S, Lun A, Preston S, Pellegrini M, Khamina K, Bergthaler A, Nutt SL, Smyth GK, Voss AK, Thomas T, Ellmeier W, Belz GT, Allan RS