This experiment comprises RNA sequencing (RNA-Seq) of two genotypes of common bean (Phaseolus vulgaris L.), BAT 477 and PÃ©rola, that have contrasting performance under drought stress. Both genotypes have Mesoamerican origin and were grown in a controlled environment (hydroponics system) for growth and induction of drought stress. The main objective of this project was to characterize the gene expression profiles of the described genotypes in response to drought stress conditions. Sequencing was performed on the platform Illumina Genome Analyzer IIx, paired-end reads with 100pb. The data were previously treated for quality assurance of the deposited reads.