Simul-seq Method

Paired DNA and RNA profiling is increasingly employed in genomics research to uncover molecular mechanisms of disease and to explore personal genotype and phenotype correlations. Here, we introduce a novel simultaneous DNA and RNA sequencing approach (Simul-seq) that enables comprehensive genomic and transcriptomic profiles from small quantities of cells or tissues. Using a variety of metrics, we demonstrate that Simul-seq produces genome-wide DNA and RNA sequencing data of high quality.

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