RNA-sequencing in WT and Fmr1-/- (KO) neurons treated with Jq1 and THZ

Widespread epigenetic disruptions in FXS mice leads to transcriptional changes that likely contribute to the neuronal phenotpyes underlying FXS. Overall design: 7DIV cultured cortical neurons from WT or Fmr1 KO mice were treated for 24 hours with vehicle, Jq1, or THZ, performed in triplicate.

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Korb E, Herre M, Zucker-Scharff I, Gresack J, Allis CD, Darnell RB