Genome-wide profiling of 2 month vs >6 month old muscle Treg cells

SRP068305

Mus musculus

8 Downloadable Samples

Illumina HiSeq 2500

Submitter Supplied Information

Description

We report age-related gene expression of Treg cells isolated from injured muscle and spleen. Male C57BL/6 Foxp3-GFP reporter mice were injured intramuscularly with cardiotoxin. Tregs were sorted directly into Trizol from injured muscle and spleen 4 days post-injury. Overall design: Gene expression profiling of muscle and splenic Tregs from 2- vs >6-month old mice (biological duplicate for each).

PubMed ID

26872699

Publication Title

Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells.

Total Samples

Submitter’s Institution

No associated institution

Authors

Kuswanto W, Burzyn D, Panduro M, Wang KK, Jang YC, Wagers AJ, Benoist C, Mathis D

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE76733

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