Effect of loss of Jmjd1c on Hoxa9/Meis1 leukemia

Analysis of gene expression profile of Hoxa9/Meis1 leukemia cells 6 days after loss of Jmjd1c. Loss of Jmjd1c induces differentiation and Hoxa9/Meis1 leukemia cells. These results provide insight into the role of Jmjd1c in AML with elelvated expression of Hoxa9. Overall design: We used primary Jmjd1c f/f Hoxa9/Meis1 neo leukemia cells from three leukemic mice and delivered Cre-Tomato by retroviral infection. We sorted Tomato positive cells 6 days after Cre infection and subjected the samples to RNA-seq.

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Zhu N, Chen M, Eng R, DeJong J, Sinha AU, Rahnamay NF, Koche R, Al-Shahrour F, Minehart JC, Chen CW, Deshpande AJ, Xu H, Chu SH, Ebert BL, Roeder RG, Armstrong SA