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Accession IconSRP064625

Newly constructed network models of different WNT signaling cascades applied to breast cancer expression data

Organism Icon Homo sapiens
Sample Icon 5 Downloadable Samples
Technology Badge IconIllumina HiSeq 2000

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Description
RNA-Seq profiling of MCF-7 and MDA-MB-231. We profiled RNA expression in the estrogen-receptor-positive (ER+) MCF-7 and the triple-negative MDA-MB-231 breast cancer cells. The objective was to find genes differentially expressed between these cell lines as potential drivers of invasiveness of the triple-negative MDA-MB-231. We further utilized the identified differential genes to validate expression-responsive module of non-canonical Wnt signaling pathway. Overall design: 2 biological replicates of MCF-7 and 3 biological replicates of MDA-MB-231
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5
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No associated institution
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