Characterization of t(15;21) translocations in myeloid disorders

SRP061835

Homo sapiens

2 Downloadable Samples

Illumina HiSeq 2500

Submitter Supplied Information

Description

We report on two novel t(15;21) alterations [t(15;21)(q24;q22) and t(15;21)(q21;q22)], which led to concurrent disruption of RUNX1 and two translocation partner genes encoding for transcription factors (SIN3A, TCF12) Overall design: Examination of four different patients with myeloid disorders. 2 out of 4 have been analyzed by means RNAseq

PubMed ID

26671595

Publication Title

t(15;21) translocations leading to the concurrent downregulation of RUNX1 and its transcription factor partner genes SIN3A and TCF12 in myeloid disorders.

Total Samples

Submitter’s Institution

No associated institution

Authors

L'Abbate A, Tolomeo D, De Astis F, Lonoce A, Lo Cunsolo C, Mühlematter D, Schoumans J, Vandenberghe P, Van Hoof A, Palumbo O, Carella M, Mazza T, Storlazzi CT

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE71551

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