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Accession IconSRP055876

Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.  

Organism Icon Mus musculus
Sample Icon 6 Downloadable Samples
Technology Badge IconIllumina Genome Analyzer IIx

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We analyzed gene expression in CD4+ cells sorted from naïve or D30 Mycobacterium tuberculosis-infected mice and incubated in vitro in the presence or absence of Schistosoma egg antigen. We found genes associated with Th1 function, T cell signaling, T cell costimulation and T cell activation were downregulated in SEA-treated cells, while expression of Th2 cytokines was below the threshold for detection. Overall design: RNAseq results for 3 replicates for naïve or CD4+ T cells from M.tuberculosis-infected mice treated with or without Schistosoma egg antigen in vitro.
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