UPF2 establishes testis-specific transcriptome enriched in transcripts with shorter 3’UTRs

This report not only adds a novel mechanism to the current dogma on achieving global shortening of 3''UTRs, but also unveils a novel function of the NMD pathway in establishing tissue-specific transcriptome identity Overall design: We first generated prospermatogonia-specific Upf2 conditional knockout mice (Ddx4-Cre; Upf2 fl/?, hereafter called Ddx4-KO) by crossing Ddx4-Cre13 with Upf2 floxed.

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Bao J, Vitting-Seerup K, Waage J, Tang C, Ge Y, Porse BT, Yan W