Molecular Effects of Doxycycline Treatment on Pterygium as Revealed by Massive Transcriptome Sequencing

SRP010038

Homo sapiens

40 Downloadable Samples

Illumina Genome Analyzer IIx

Submitter Supplied Information

Description

A total of 332 genes were identified which modified their expression in a dose-dependent manner upon exposure to doxycycline. The more represented cellular pathways included all mitochondrial genes, the endoplasmic reticulum stress response, integrins and extracellular matrix components, and growth factors. Overall design: Examination of 4 different doses of doxycycline in ten human pterygium samples.

PubMed ID

25358733

Publication Title

Transcriptomic profiling explains racial disparities in pterygium patients treated with doxycycline.

Total Samples

Submitter’s Institution

No associated institution

Authors

Larrayoz IM, Rúa Ó, Velilla S, Martínez A

Source Repository

Sequence Read Archive (SRA)

Alternate Accession IDs

GSE34736

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