VSartorelli SMC Calorie Restriction

GSE9756

Mus musculus

24 Downloadable Samples

Affymetrix Mouse Expression 430B Array (moe430b), Affymetrix Mouse Expression 430A Array (moe430a)

Submitter Supplied Information

Description

The integration of positive and negative intra- and extra-cellular signals dictates whether a cell will proliferate or differentiate. While it is intuitive to speculate that nutrients availability may influence this alternative, a comprehensive complement of the molecular determinants involved in this process has not been elucidated yet. In this study, we will investigate how nutrients (glucose) affect skeletal myogenesis. C2C12 cells will be cultured in high glucose and low glucose conditions, and their differenciation will be studied.

PubMed ID

18477450

Publication Title

Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt.

Total Samples

Submitter’s Institution

Children's National Medical Center

Authors

Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-9756

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