Expression data from acd, p53 and double mutant mouse embryos

In mouse, the adrenocortical dysplasia (acd) phenotype shows limb and body axis anomalies, as a result of p53-dependent apoptosis, and perinatal lethality. The p53 deficiency partially rescues anomalies, but not perinatal lethality, implicating the involvement of p53-independent mechanisms in the acd phenotype. Differentially expressed genes in acd mutant and double mutant embryos were identified. p53-dependent and independent pathways contributing to acd phenotype were characterized.

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Sucularli C, Thomas P, Kocak H, White JS, O'Connor BC, Keegan CE