Identification of biological markers of sensitivity to high-clinical-risk-adapted therapy for DLBCL patients

Diffuse large B-cell lymphoma (DLBCL) has striking clinical and molecular variability. Although a more precise identification of the multiple determinants of this variability is still under investigation, there is a consensus that high-clinical-risk DLBCL cases require a risk-adapted therapy, since intensification of chemotherapy with autologous stem-cell transplantation (ASCT) has been shown to improve the prognosis for high-risk patients in randomised clinical trials.

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Saez AI, García-Cosío M, Sáez AJ, Hernández JM, Sánchez-Verde L, Alvarez D, de la Cueva P, Arranz R, Conde E, Grande C, Rodríguez J, Caballero D, Piris MA