Expression profile from anthrax edema toxin (ET) treated murine bone marrow derived macrophages (BMDM)

Bacillus anthracis, the causative agent of anthrax, secretes three toxin proteins: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA is a transporter of LF and EF into host cells by receptor-mediated endocytosis. LF is a metalloprotease that cleaves mitogen-activated protein kinase (MAPK) kinases (MKK), while EF is an adenylate cyclase, which converts ATP to cAMP.

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Kim C, Wilcox-Adelman S, Sano Y, Tang WJ, Collier RJ, Park JM