Effect of loss of CREB and CREM on cocaine-induced gene expression in the striatum

GSE8948

Mus musculus

55 Downloadable Samples

Affymetrix Murine Genome U74A Version 2 Array (mgu74av2), Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Submitter Supplied Information

Description

Ablation of the Creb1 gene in forebrain neurons was performed using the Cre/loxP system, with the recombinase expressed from the Camk2alfa promoter. Mice were crossed into the Crem KO background to prevent compensation of CREB loss by CREM overexpression.

PubMed ID

18424767

Publication Title

CREB has a context-dependent role in activity-regulated transcription and maintains neuronal cholesterol homeostasis.

Total Samples

Submitter’s Institution

German Cancer Research Center

Authors

Lemberger T, Parkitna JR, Chai M, Schütz G, Engblom D

Source Repository

Gene Expression Omnibus (GEO)

Alternate Accession IDs

E-GEOD-8948

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