Transcriptional regulation by the novel Rho GTPase RhoBTB2.

RhoBTB2 is a novel Rho GTPase that undergoes loss, underexpression and mutation in breast and lung cancer. We have shown that we can mimic loss of RhoBTB2 through siRNA treatment of primary cells. We propose to perform comparative microarray analysis of primary lung cells to establish the identification of the gene targets of RhoBTb2 regulation.

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McKinnon CM, Lygoe KA, Skelton L, Mitter R, Mellor H