Expression data from transdetermined Drosophila eye antennal imaginal disc by winged eye overexpression.

Drosophila imaginal disc cells exhibit a remarkable ability to switch cell fates under various perturbations, a phenomenon known as transdetermination (TD). The winged eye (wge) gene induces eye-to-wing TD by its overexpression in eye imaginal discs using eye specific Gal4 driver (eyeless-Gal4). Gene network controlling this process, however, is largely unclear. Additionally, we identified that heterochromatin-related histone methyltransferase Su(var)3-9 is essential for wge-mediated TD.

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Masuko K, Fuse N, Komaba K, Katsuyama T, Nakajima R, Furuhashi H, Kurata S