Gene expression in mouse 3T3-L1 adipocyte tissue culture treated with tunicamycin

Tunycamcin induces UPR/ISR and Inflammation in mouse 3T3-L1 adipocyte tissue culture. The early transcriptome changes were analyzed using high-density microarrays to better characterize the signaling pathways responding to tunicamycin, to be compared with similar experiments with CLA as the treatment. Their gene expression responses between 4 to 12 hr after treatment showed a common set of early gene expression changes indicative of a UPR/Inflammation stress response.

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LaRosa PC, Riethoven JJ, Chen H, Xia Y, Zhou Y, Chen M, Miner J, Fromm ME