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Accession IconGSE86522

Gene expression profile of A549 cells cultured with normal 2D condition and xenografted tumor tissue

Organism Icon Homo sapiens
Sample Icon 1 Downloadable Sample
Technology Badge Icon Affymetrix Human Gene 2.0 ST Array (hugene20st)

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Preclinical cancer drug discovery efforts have employed two-dimensional (2D)-cell-based assay models, which fail to forecast in vivo efficacy and contribute to a lower success rates of clinical approval. Three-dimensional (3D) cell culture models are recently expected to bridge the gap between 2D and in vivo models. We compared between A549 cells cultured in ordinal 2D condition and xenografted tumor tissue.
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