PRDM16 represses the type I Interferon response in adipocytes [expression profiling]

PRDM16 is a strong activator of brown fat-specific genes, while also a repressor of white fat and muscle-specific genes. We asked what other pathways are regulated by PRDM16 in adipocytes that may be critical for brown and/or beige adipogenesis. Using microarray, we found PRDM16 also represses type I Interferon-stimulated genes (ISGs) in adipocytes.

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Kissig M, Ishibashi J, Harms MJ, Lim HW, Stine RR, Won KJ, Seale P